Magnetic Resonance Spectroscopy: An Insight in CellFocal Adhesions

Autor:: Zhang Ziwei
Wydawnictwo:: VDM Verlag
Liczba stron:: 148
Format:: 220 mm x 150 mm x 9 mm
ISBN-13/EAN:: 9783639079197
ISBN-10:: 3639079191
Rok wydania:: wrzesień 2008 r.
Waga:: 237 g
Realizacja:: ok. 7-10 dni + wysyłka

Magnetic Resonance Spectroscopy: An Insight in CellFocal Adhesions, wrzesień 2008 r. : Focal Adhesion (FA) plays a central role in cell
attachment and migration; it controls embryogenesis,
tissue repair, inflammatory response and tumor
invasion. Cell migrates through the regulated
alternative assembly and disassembly of Focal
Adhesion. It pulls the cell body forward by grabbing
and releasing Extra-Cellular Matrix (ECM). For its
importance, the mechanism of FA controlling has been
a major research focus during the past 10 years.
However, the fundamental question of how the FA
assembly and disassembly are precisely controlled
remains unanswered. PAK, FAK, Paxillin and GIT1 are
important structural and signaling components in FA.
To answer the critical question in the field of cell
adhesion and migration, Nuclear Magnetic Resonance
(NMR) Spectroscopy is used to study the structures
and regulations between these proteins. This book
focuses on the structural and functional study of
GIT1 and discusses the Focal Adhesion control through
some novel discoveries. For the first time, this
work has consolidated existing evidences, including
some controversial findings, to provide an exciting
working model on the FA regulation.

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