HYPNOTIC, ANALGESIC, AND EEG ENDPOINTSDURING INTRAVENOUS ANAESTHESIA

Autor:: Mustola Seppo
Wydawnictwo:: VDM Verlag
Liczba stron:: 100
Format:: 220 mm x 150 mm x 6 mm
ISBN-13/EAN:: 9783639087536
ISBN-10:: 3639087534
Rok wydania:: październik 2008 r.
Waga:: 165 g
Realizacja:: ok. 7-10 dni + wysyłka

HYPNOTIC, ANALGESIC, AND EEG ENDPOINTSDURING INTRAVENOUS ANAESTHESIA, październik 2008 r. : In this study, differences, effective doses, and
concentrations of propofol and thiopental in
hypnotic, analgesic, and EEG end-point were
evaluated. Nine rabbits, and 143 patients were
studied. In rabbits propofol revealed to be the best
choice because recovery was rapid and breathing
patterns were well preserved. In humans propofol
attenuated better the catecholamine response (CA) to
tracheal intubation (TI) than thiopental. The CA
response to TI was almost totally blocked during
burst suppression pattern (BSP) of EEG induced by
propofol. At BSP level thiopental attenuated the
cardiovascular response to TI nearly as well as
propofol. Remifentanil infusion started before
propofol significantly reduced times and doses of
propofol at the attainment of differrent endpoints.
Remifentanil also affects the BIS value and might be
kinetically useful for loss of consciousness because
it accelerates the hypnotic onset of propofol.
Propofol and thiopental have similarities in BSP but
during propofol 13-15 Hz spindle oscillations are
seen. An algorithm for automatic detection of BSP
was developed.

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